Hidrogeles: propiedades, clasificación y avances recientes.
DOI:
https://doi.org/10.32870/recibe.v14i3.444Palabras clave:
Hidrogeles, Nanogeles, Liberación Controlada, Aplicaciones biomédicasResumen
Esta mini revisión presenta una visión global de los hidrogeles, materiales poliméricos que han atraído la atención en gran medida por las múltiples aplicaciones en las cuales intervienen sobre todo en el área biomédica. Se abordan las definiciones básicas, clasificación, propiedades y mecanismos de respuesta a estímulos externos tales como cambios en el pH del medio, cambios de temperatura, presión y sensibilidad a las enzimas debido a su relevancia en la administración de fármacos, medicina regenerativa y las estrategias terapéuticas emergentes. Se presentan los avances recientes en las aplicaciones biomédicas y los retos en su aplicación clínica. La multifuncionalidad y la adaptabilidad de estos materiales resalta su rol en el desarrollo de las nuevas generaciones de tecnologías para la medicina personalizada y de precisión.Citas
Jiang, Y., Li, H., Wang, X., & Wang, Y. (2023). A review of the development of biopolymer hydrogel-based systems for biomedical applications. Gels, 11(3), 178. https://doi.org/10.3390/gels11030178
Nugroho, F. A. A., Rizky, F. S. A., Gozan, M., & Budiman, A. (2022). Novel trends in hydrogel development for biomedical applications. Polymers, 14(15), 3023. https://doi.org/10.3390/polym14153023
Fan, L., Yang, J., Wu, H., Hu, Z., Yi, J., & Tong, C. (2022). Hydrogels: Properties and applications in biomedicine. Molecules, 27(9), 2902. https://doi.org/10.3390/molecules27092902
Owens, D. E., Jian, Y., Fang, J. E., Slaughter, B. V., Chen, Y. H., & Peppas, N. A. (2007). Thermally responsive swelling properties of polyacrylamide/poly (acrylic acid) interpenetrating polymer network nanoparticles. Macromolecules, 40(20), 7306-7310.
Ho, T. C., Pelton, R., & Huson, M. G. (2022). Hydrogels: Properties and Applications in Biomedicine. Molecules, 27(9), 2902. https://doi.org/10.3390/molecules27092902
Zhang, Z., Liu, Y., Wang, Y., & Liu, Y. (2018). Influence of Network Structure on the Crystallization Behavior of PEG-Based Hydrogels. Polymers, 10(9), 970. https://doi.org/10.3390/polym10090970
Hou, Y., Huang, Y., Ma, Y., Shuai, X., Shen, J., & Yang, W. (2022). Construction and Ion Transport-Related Applications of the Hydrogels. Polymers, 14(19), 4037. https://doi.org/10.3390/polymers14194037
Gori, M., Donnadio, A., Iacopetti, P., Basoli, F., Zuppolini, S., & Lamberti, A. (2022). A soft zwitterionic hydrogel as potential coating on implantable neuroprostheses. Molecules, 27(10), 3126. https://doi.org/10.3390/molecules27103126
Xie, M., Liu, Q., Liu, X., Li, C., Zhang, Q., & Zhang, Q. (2024). Hydrogel composites for multifunctional biomedical applications. Materials, 8(4), 154. https://doi.org/10.3390/ma8040154
Omidian, H., Chowdhury, S. D., & Wilson, R. L. (2024). Advancements and Challenges in Hydrogel Engineering for Regenerative Medicine. Gels, 10(4), 238. https://doi.org/10.3390/gels10040238
Giordano, S., Terracciano, M., Gallo, E., Diaferia, C., Falanga, A. P., Accardo, A., Franzese, M., Salvatore, M., Piccialli, G., Borbone, N., & Oliviero, G. (2025). Investigating the interactions of peptide nucleic acids with multicomponent peptide hydrogels for the advancement of healthcare technologies. Gels, 11(5), 367. https://doi.org/10.3390/gels11050367
Dell, A. C., Wagner, G., Own, J., & Geibel, J. P. (2022). 3D Bioprinting Using Hydrogels: Cell Inks and Tissue Engineering Applications. Pharmaceutics, 14(12), 2596. https://doi.org/10.3390/pharmaceutics14122596
Mohan, A., Santhamoorthy, M., Phan, T. T. V., & Kim, S.-C. (2024). NIPAm-Based pH and Thermoresponsive Copolymer Hydrogel for Hydrophobic and Hydrophilic Drug Delivery. Gels, 10(2), 184. https://doi.org/10.3390/gels10020184
Rafael, D., Melendres, M. M. R., Andrade, F., Montero, S., Martinez-Trucharte, F., Vilar-Hernandez, M., Durán-Lara, E.F., Schwartz Jr, S., & Abasolo, I. (2021). Thermo-Responsive Hydrogels for Cancer Local Therapy: Challenges and State-of-Art. Int. J. Pharm., 606, 120954. https://doi.org/10.1016/j.ijpharm.2021.120954
Sipos, B., Budai-Szűcs, M., Katona, G., & Csóka, I. (2025). Gellan Gum-Based In Situ Hydrogels for Nasal Delivery of Polymeric Micelles Loaded with Risperidone. Gels, 11(6), 404. https://doi.org/10.3390/gels11060404
Varughese, A., Sekhar, S. S., & Radhakrishnan, E. K. (2025). Development and Characterization of Chitosan-Based In Situ Gelling Systems for Periodontal Drug Delivery. Gels, 11(3), 281. https://doi.org/10.3390/gels11030281
Encinas-Basurto, D., Ruiz, V. H., Schnellmann, R. G., & Mansour, H. M. (2025). Evaluation of Carboxymethyl Chitosan–Genipin Hydrogels as Reservoir Systems for Suramin Delivery in Epithelial Tissues. Gels, 11(5), 312. https://doi.org/10.3390/gels11050312
Rhinow, R., Franco, M. K. K. D., Vollrath, M. K., Kellermann, G., & Yokaichiya, F. (2025). Poloxamer-Driven Drug Delivery System for Anti-Inflammatory Drugs Using Small-Angle Neutron Scattering Approach. Gels, 11(6), 410. https://doi.org/10.3390/gels11060410
Plugariu, D.-V., Zgura, I., Mihaila, I., Bucur, B., Iovu, H., & Vasile, B. S. (2025). Injectable thermo-sensitive hydrogel based on graphene oxide functionalized with hyaluronic acid for local release of ketorolac tromethamine. Pharmaceutics, 17(2), 360. https://doi.org/10.3390/pharmaceutics17020360.
Esparza-Villalpando, V., Pozos-Guillén, A., Vértiz-Hernández, Á. A., Vega-Baudrit, J., & Chavarría-Bolaños, D. (2025). Design of a dual-drug delivery system for local release of chlorhexidine and dexketoprofen. Polymers, 17(13), 1771. https://doi.org/10.3390/polym17131771.
Viezuina, D.-M., Musa, I., Aldea, M., Matache, I.-M., Rotaru Zavaleanu, A.-D., Gresita, A., Veronica, S., & Mitran, S. I. (2025). Gelatin-based hydrogels for peripheral nerve regeneration: A multifunctional vehicle for cellular, molecular, and pharmacological therapy. Gels, 11(7), 490. https://doi.org/10.3390/gels11070490.
Radojković, N., Spasojević, J., Vukoje, I., Kačarević-Popović, Z., Stamenović, U., Vodnik, V., Roglić, G., & Radosavljević, A. (2025). Gamma irradiation-induced synthesis of nano Au-PNiPAAm/PVA bi-layered photo-thermo-responsive hydrogel actuators with a switchable bending motion. Polymers, 17(13), 1774. https://doi.org/10.3390/polym17131774
Kawaguchi, H. (2020). On going to a new era of microgel exhibiting volume phase transition. Gels, 6(3), 26. https://doi.org/10.3390/gels6030026
Stolic, A., Rogic Miladinovic, Z., Krstic, M., Stamboliev, G., Petrovic, V., & Suljovrujic, E. (2025). Radiation-induced synthesis of polymer networks based on thermoresponsive ethylene glycol propylene glycol monomers. Gels, 11(7), 488. https://doi.org/10.3390/gels11070488
Dušek, K., & Dušková-Smržová, M. (2020). Volume phase transition in gels: Its discovery and development. Gels, 6(3), 22. https://doi.org/10.3390/gels6030022
Zuckerman, S. T., Rivera-Delgado, E., Haley, R. M., Korley, J. N., & von Recum, H. A. (2020). Elucidating the structure-function relationship of solvent and cross-linker on affinity-based release from cyclodextrin hydrogels. Gels, 6(1), 9. https://doi.org/10.3390/gels6010009
Costa, M. C. M., Silva, S. M. C., Almeida, L. C., & Antunes, F. E. (2025). Injectable and printable thermoresponsive hydrogel composites reinforced with nanoclays for biomedical applications. Gels, 11(4), 312. https://doi.org/10.3390/gels11040312.
Chaji, S., Al-Saleh, J., & Gomillion, C. T. (2020). Bioprinted three-dimensional cell-laden hydrogels to evaluate adipocyte–breast cancer cell interactions. Gels, 6(1), 10. https://doi.org/10.3390/gels6010010
Pinelli, F., Perale, G., & Rossi, F. (2020). Coating and functionalization strategies for nanogels and nanoparticles for selective drug delivery. Gels, 6(1), 6. https://doi.org/10.3390/gels6010006
Pawlik, A., Malina, D., Strzelecka, M., & Tomczykowa, M. (2025). Thermoresponsive hydrogels based on poly(N-isopropylacrylamide) for controlled drug delivery systems. Gels, 11(1), 45. https://doi.org/10.3390/gels11010045.
Li, Y., Wang, J., & Liu, S. (2025). Synthesis of Temperature/pH Dual-Responsive Double-Crosslinked Hydrogel on Medical Titanium Alloy Surface. Gels, 11(6), 443. https://doi.org/10.3390/gels11060443.
Zhi, Y., Zhang, Q., & Cao, J. (2025). pH-Responsive Injectable Hydrogels for Localized Cancer Therapy: Strategies and Applications. Gels, 11(5), 370. https://doi.org/10.3390/gels11050370
Piszko, P. J., Kulus, M., Piszko, A., Kiryk, J., Kiryk, S., Kensy, J., Małyszek, A., Michalak, M., Do brzyński, W., Matys, J., & Dobrzyński, M. (2025). The Influence of Calcium Ions and pH on Fluoride Release from Commercial Fluoride Gels in an In Vitro Study. Gels, 11(7), 486. https://doi.org/10.3390/gels11070486
Anantaworasakul, P., Preedalikit, W., Anantaworasakul, P., Singh, S., Intharuksa, A., Arunotayanun, W., Na Takuathung, M., Yotsawimonwat, S., & Chittasupho, C. (2025). Phytochemical Characterization, Bioactivities, and Nanoparticle-Based Topical Gel Formulation Development from Four Mitragyna speciosa Varieties. Gels, 11(7), 494. https://doi.org/10.3390/gels11070494
Sobczak, M. (2022). Enzyme-responsive hydrogels as potential drug delivery systems—State of knowledge and future prospects. Int. J. Mol. Sci., 23(8), 4421. https://doi.org/10.3390/ijms23084421
Khodeir, M., Jia, H., Vlad, A., & Gohy, J.-F. (2021). Application of redox-responsive hydrogels based on 2,2,6,6-tetramethyl-1-piperidinyloxy methacrylate and oligo(ethyleneglycol) methacrylate in controlled release and catalysis. Polymers, 13(8), 1307. https://doi.org/10.3390/polym13081307
Song, W., You, J., Zhang, Y., Yang, Q., Jiao, J., & Zhang, H. (2022). Recent studies on hydrogels based on H₂O₂-responsive moieties: Mechanism, preparation and application. Gels, 8(6), 361. https://doi.org/10.3390/gels8060361
Psarrou, M., Mitraki, A., Vamvakaki, M., & Kokotidou, C. (2023). Stimuli-responsive polysaccharide hydrogels and their composites for wound healing applications. Polymers, 15(4), 986. https://doi.org/10.3390/polym15040986